Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02180-0002-0000-5 |
Chemical Name: | Fluometuron |
CASRN: | 2164-17-2 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 054432_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Fluometuron | 238 | 200 | 4 | 0.020 | 2.0 | 1 | 0.005 | 0.5 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 |
715 | 200 | 14 | 0.070 | 2.5 | 0 | 0.000 | 0.0 | 4 | 0.020 | 2.0 | 10 | 0.050 | 1.0 | ||
2380 | 200 | 7 | 0.035 | 3.0 | 0 | 0.000 | 0.0 | 6 | 0.030 | 2.5 | 1 | 0.005 | 1.0 | ||
Positive Control: | Mitomycin-C | 1 | 35 | 205 | 5.857 | 94.0 | 26 | 0.743 | 48.6 | 29 | 0.829 | 42.9 | 150 | 4.286 | 15.0 |
Mitomycin-C | 5 | 15 | 88 | 5.867 | 100.0 | 3 | 0.200 | 20.0 | 11 | 0.733 | 20.0 | 74 | 4.933 | 11.0 | |
Trend: | 1.805 | -1.258 | 2.079 | ||||||||||||
Probability: | 0.036 | 0.896 | 0.019 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 4 | 0.020 | 2.0 | 2 | 0.010 | 1.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Fluometuron | 238 | 200 | 15 | 0.075 | 4.5 | 3 | 0.015 | 1.0 | 12 | 0.060 | 4.0 | 0 | 0.000 | 0.0 |
715 | 200 | 3 | 0.015 | 1.5 | 1 | 0.005 | 0.5 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
2380 | 200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 50 | 50 | 35 | 0.700 | 44.0 | 9 | 0.180 | 18.0 | 24 | 0.480 | 32.0 | 2 | 0.040 | 1.0 |
Trend: | -1.271 | -0.728 | -1.116 | ||||||||||||
Probability: | 0.898 | 0.767 | 0.868 |