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Study Information
Study Attribute Value
CEBS Accession Number: 002-02180-0008-0000-1
Chemical Name: Fluometuron
CASRN: 2164-17-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 134145
Study Result: Negative


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Negative
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 70 104 160 77 60
    90 96 139 52
    95 106 123 43
    78 95 162 69
Test Chemical Fluometuron 
62.5       
 69 86 122 59 59
    70 88 124 59
  
125         
 79 95 108 46 52
    80 90 140 58
  
250         
 95 82 174 61 65
    83 93 168 68
  
500         
 89 24 142 53 50
    96 25 133 46
  
1000         
   
Positive Control Methyl Methane Sulfonate 
15         
 42 27 302 243 246*
    39 24 289 249

Nonactivation Trial: 2 Experiment Call: Negative
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 69 101 95 46 45
    69 92 89 43
    69 102 90 44
    65 105 94 48
Test Chemical Fluometuron 
50         
 51 68 106 70 57
    79 89 107 45
  
200         
 69 81 72 35 48
    55 71 101 62
  
350         
 66 15 98 50 52
    59 14 95 54
  
500         
 54 11 97 60 51
    51 38 64 42
  
800         
   
Positive Control Methyl Methane Sulfonate 
15         
 27 22 218 271 251*
    31 21 212 230

Induced S9 Trial: 1 Experiment Call: Negative
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 87 100 176 67 64
    98 96 172 58
    71 105 122 57
    81 99 175 72
Test Chemical Fluometuron 
50         
 92 101 119 43 49
    94 111 156 55
  
200         
 102 97 181 59 61
    89 93 170 63
  
350         
 80 59 132 55 56
    77 67 129 56
  
500         
 78 32 146 62 67
    59 23 127 72
  
650         
 59 8 125 70 116*
    44 7 216 162
  
800         
   
Positive Control 3-Methylcholanthrene 
2.5       
 61 63 599 329 295*
    80 63 625 262

Induced S9 Trial: 2 Experiment Call: Negative
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 98 92 31 11 17
    103 102 74 24
    105 103 59 19
    104 103 45 14
Test Chemical Fluometuron 
100         
 84 76 56 22 18
    78 72 32 14
  
200         
 78 66 45 19 20
    73 67 46 21
  
300         
 67 57 49 24 25
    73 62 58 27
  
400         
 69 16 60 29 23
    76 35 40 18
  
500         
 124r 38 73 20
    139r 65 61 15
Positive Control 3-Methylcholanthrene 
2.5       
 71 30 280 131 134*
    58 34 240 137

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination