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Study Information
Study Attribute Value
CEBS Accession Number: 002-02185-0001-0000-9
Chemical Name: Formaldehyde
CASRN: 50-00-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 378046_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Questionable 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 07/05/1981    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1041 417 0.401 8.34 25.5 0.000
Test Chemical Formaldehyde 
 0.37      
 50 1035 483 0.467 9.66 25.5 16.499 
1.1       
 50 1048 520 0.496 10.40 25.5 23.867 
3.69      
 50 1043 736 0.706 14.72 25.5 76.160
Positive Control Triethylenemelamine 
 0.015     
 50 1054 1934 1.835 38.68 25.5 358.069
Trend: 9.549        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 07/23/1981    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1034 377 0.365 7.54 25.8 0.000
Test Chemical Formaldehyde 
6         
 50 1041 426 0.409 8.52 25.8 12.238 
8         
 50 1041 650 0.624 13.00 25.8 71.254 
11         
 50 1039 941 0.906 18.82 25.8 148.401
Positive Control Triethylenemelamine 
 0.015     
 50 1041 2312 2.221 46.24 25.8 509.139
Trend: 17.488        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/05/1981    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1030 408 0.396 8.16 26.0 0.000
Test Chemical Formaldehyde 
 0.369     
 50 1036 344 0.332 6.88 26.0 -16.175 
1.1       
 50 1024 391 0.382 7.82 26.0 -3.605 
3.69      
 50 1033 490 0.474 9.80 26.0 19.749
Positive Control Cyclophosphamide 
1.5       
 50 1025 1694 1.653 33.88 26.0 317.221
Trend: 3.287        
Probability: 0.001        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 07/23/1981    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1021 462 0.452 9.24 25.5 0.000
Test Chemical Formaldehyde 
6         
 50 1043 506 0.485 10.12 25.5 7.214 
8         
 50 1034 600 0.580 12.00 25.5 28.237 
11         
 50 1020 706 0.692 14.12 25.5 52.964
Positive Control Cyclophosphamide 
1.5       
 50 1041 1844 1.771 36.88 25.5 291.466
Trend: 7.847        
Probability: 0.000