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Study Information
Study Attribute Value
CEBS Accession Number: 002-02185-0002-0000-0
Chemical Name: Formaldehyde
CASRN: 50-00-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 378046_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Weakly Positive 

Trial #:1   Activation: No Activation    Date: 07/08/1981    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 7 0.070 4.0 1 0.010 1.0 6 0.060 4.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 8 0.080 5.0 5 0.050 3.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: Formaldehyde 
1.1       
 100 10 0.100 4.0 1 0.010 1.0 9 0.090 3.0 0 0.000 0.0 
3.69      
 100 9 0.090 8.0 7 0.070 6.0 2 0.020 2.0 0 0.000 0.0 
11         
 100 6 0.060 6.0 2 0.020 2.0 4 0.040 4.0 0 0.000 0.0
Positive Control: Triethylenemelamine 
 0.5       
 100 32 0.320 21.0 14 0.140 12.0 18 0.180 12.0 0 0.000 0.0
Trend: 0.691 0.301 0.247  
Probability: 0.245 0.382 0.402  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/06/1981    Harvest Time: 10.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Formaldehyde 
15         
 100 10 0.100 8.0 2 0.020 2.0 7 0.070 6.0 1 0.010 1.0 
20         
 100 14 0.140 12.0 7 0.070 7.0 6 0.060 3.0 1 0.010 1.0 
25         
 100 54 0.540 26.0 36 0.360 24.0 8 0.080 6.0 10 0.100 1.0
Positive Control: Cyclophosphamide 
25         
 100 30 0.300 23.0 16 0.160 15.0 8 0.080 7.0 6 0.060 6.0
Trend: 5.159 5.823 1.322  
Probability: 0.000 0.000 0.093  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 07/08/1981    Harvest Time: 10.5 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Medium 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: Formaldehyde 
1.1       
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
3.69      
 100 4 0.040 4.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 
11         
 100 11 0.110 8.0 8 0.080 7.0 3 0.030 2.0 0 0.000 0.0 
36.9       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
25         
 100 19 0.190 17.0 10 0.100 10.0 9 0.090 8.0 0 0.000 0.0
Trend: 2.266 3.123 0.172  
Probability: 0.012 0.001 0.432