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Study Information
Study Attribute Value
CEBS Accession Number: 002-02185-0003-0000-1
Chemical Name: Formaldehyde
CASRN: 50-00-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 590863_SCE
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 09/23/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 524 0.499 10.48 26.0 0.000
Test Chemical Formaldehyde 
 0.5       
 50 1050 546 0.520 10.92 26.0 4.198 
1.6       
 50 1050 415 0.395 8.30 26.0 -20.802 
5         
 50 1049 595 0.567 11.90 26.0 13.658
Positive Control Triethylenemelamine 
 0.015     
 50 1050 1437 1.369 28.74 26.0 174.237
Trend: 0.797        
Probability: 0.213        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/23/1981    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 100 2097 915 0.436 9.15 26.0 0.000
Test Chemical Formaldehyde 
1.6       
 50 1046 504 0.482 10.08 26.0 10.427 
5         
 50 1048 523 0.499 10.46 26.0 14.371 
16         
 100 2095 1266 0.604 12.66 28.0 38.493
Positive Control Cyclophosphamide 
1         
 100 2095 2593 1.238 25.93 26.0 183.659
Trend: 7.540        
Probability: 0.000