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Study Information
Study Attribute Value
CEBS Accession Number: 002-02189-0001-0000-3
Chemical Name: Formulated fenaminosulf
CASRN: 140-56-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 386052_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 10/01/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1049 429 0.409 8.58 26.0 0.000
Test Chemical Formulated fenaminosulf 
1.6       
 50 1049 436 0.416 8.72 26.0 1.632 
5         
 50 1049 581 0.554 11.62 26.0 35.431 
16         
 50 1050 728 0.693 14.56 26.0 69.535 
50         
 27 566 493 0.871 18.26 26.0 112.985 
160         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1052 521 0.495 10.42 26.0 21.099
Mitomycin-C 
 0.005     
 10 209 248 1.187 24.80 26.0 190.151
Trend: 14.033        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 12/12/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1043 372 0.357 7.44 26.5 0.000
Test Chemical Formulated fenaminosulf 
10         
 50 1049 474 0.452 9.48 26.5 26.691 
16         
 50 1046 454 0.434 9.08 26.5 21.693 
30         
 50 1044 574 0.550 11.48 26.5 54.153 
50         
 50 1041 538 0.517 10.76 31.5 44.902
Positive Control Mitomycin-C 
 0.0E-4    
 50 1048 629 0.600 12.58 26.5 68.279
Mitomycin-C 
 0.005     
 10 210 289 1.376 28.90 26.5 285.851
Trend: 6.364        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/01/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1049 447 0.426 8.94 26.0 0.000
Test Chemical Formulated fenaminosulf 
50         
 50 1049 530 0.505 10.60 26.0 18.568 
160         
 50 1049 575 0.548 11.50 26.0 28.635 
500         
 50 1049 677 0.645 13.54 26.0 51.454 
1600         
 50 1049 870 0.829 17.40 26.0 94.631
Positive Control Cyclophosphamide 
 0.15      
 50 1049 728 0.694 14.56 26.0 62.864
Cyclophosphamide 
 0.6       
 10 210 280 1.333 28.00 26.0 212.901
Trend: 12.613        
Probability: 0.000