Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02189-0002-0000-4 |
Chemical Name: | Formulated fenaminosulf |
CASRN: | 140-56-7 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 386052_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 2 | 0.010 | 0.5 | 0 | 0.000 | 0.0 | 2 | 0.010 | 0.5 | 0 | 0.000 | 0.0 |
Test Chemical: | Formulated fenaminosulf | 160 | 200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
300 | 200 | 5 | 0.025 | 2.5 | 1 | 0.005 | 0.5 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
500 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.0625 | 200 | 13 | 0.065 | 6.0 | 4 | 0.020 | 2.0 | 9 | 0.045 | 4.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.125 | 50 | 5 | 0.100 | 10.0 | 5 | 0.100 | 10.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | |
Trend: | 0.529 | 0.032 | 0.582 | ||||||||||||
Probability: | 0.298 | 0.487 | 0.280 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Formulated fenaminosulf | 500 | 200 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 |
1000 | 200 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | ||
1600 | 200 | 4 | 0.020 | 2.0 | 2 | 0.010 | 1.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 5 | 200 | 41 | 0.205 | 17.5 | 11 | 0.055 | 5.0 | 30 | 0.150 | 13.0 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 7.5 | 50 | 14 | 0.280 | 24.0 | 4 | 0.080 | 8.0 | 10 | 0.200 | 18.0 | 0 | 0.000 | 0.0 | |
Trend: | 0.764 | 1.800 | 0.027 | ||||||||||||
Probability: | 0.222 | 0.036 | 0.489 |