COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02189-0008-0000-0
Chemical Name: Formulated fenaminosulf
CASRN: 140-56-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 321970
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Negative
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 105 123 94 30 31
    85 79 79 31
    93 105 87 31
    68 93 66 33
Test Chemical Formulated fenaminosulf 
25         
 92 60 119 43 42
    88 64 136 52
    91 64 88 32
  
50         
 118 65 95 27 30
    102 77 97 32
    101 60 94 31
  
75         
 108 52 126 39 33
    113 68 117 35
    104 57 80 26
  
100         
 117 66 167 48 45
    124r 58 197 53
    100 56 129 43
  
150         
 109 45 140 43 38
    119 56 142 40
    112 45 111 33
  
200         
 102 39 149 49 45
    98 27 146 50
    111 29 119 36
Positive Control Methyl Methane Sulfonate 
5         
 67 50 465 231 304*
    66 37 885 450
    78 62 542 232

Nonactivation Trial: 2 Experiment Call: Inconclusive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 89 99 96 36 31
    106 101 107 34
    92 103 75 27
    110 97 95 29
Test Chemical Formulated fenaminosulf 
25         
 100 92 94 31 34
    120 72 115 32
    92 57 110 40
  
50         
 110 64 135 41 39
    109 59 124 38
  
75         
 107 74 105 33 33
    128r 61 150 39
    110 73 112 34
  
100         
 128r 67 108 28 36
    117 57 115 33
    112 56 134 40
  
150         
 111 56 99 30 31
    114 46 111 33
    120r 60 136 38
  
200         
 106 45 177 56 45
    107 45 144 45
    111# 43 119 36
Positive Control Methyl Methane Sulfonate 
5         
 73 51 513 236 257*
    71 40 566 264
    79 51 637 270

Induced S9 Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 105 59 119 38 32
    98 111 91 31
    113 130 89 26
    121r 258 74 20
Test Chemical Formulated fenaminosulf 
25         
 60 91 106 59 59*
    94 70 211 75
    63 58 84 44
  
50         
 111 138 234 71 76*
    74 45 213 96
    66 71 123 62
  
75         
 98 76 349 118 146*
    113 88 320 95
    69 36 465 226
  
100         
 76 44 335 147 118*
    127r 73 310 81
    103 87 274 89
  
150         
 63# 38 422 223 144*
    64 32 228 119
    64 42 175 91
  
200         
 65 15 292 150 152*
    99 34 286 96
    40 5 252 210
Positive Control 3-Methylcholanthrene 
2.5       
 54 17 504 311 217*
    110 35 489 149
    84 28 482 191

Induced S9 Trial: 2 Experiment Call: Inconclusive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 9r 17 145 547 56
    58 102 134 78
    3r 7 132 1389
    85 98 87 34
Test Chemical Formulated fenaminosulf 
25         
 120 191 146 41 37
    115 190 87 25
    101 198 134 44
  
50         
 97 177 151 52 60
    103 157 180 58
    111 120 234 70
  
75         
 88 134 184 70 75
    93 168 198 71
    93 140 236 84
  
100         
 94 144 220 78 79
    107 162 255 80
    113 158 269 79
  
150         
 36 10 195 181 97*
    115# 159 285 83
    115 139 93 27
  
200         
 117# 128 119 34 62
    59 79 165 93
    120 186 215 60
Positive Control 3-Methylcholanthrene 
2.5       
 8r 6 343 1429 1073*
    4r 4 211 1835
    15 15 488 1073

Induced S9 Trial: 3 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 123r 124 181 49 69
    99 96 219 74
    99 101 184 62
    79 103 170 72
Test Chemical Formulated fenaminosulf 
25         
 106 85 321 101 112*
    105 95 366 116
    96 84 345 120
  
50         
 109 64 489 149 138*
    116 80 481 139
    111 81 417 125
  
75         
 126r 77 556 147
    121r 75 468 129
    115 69 469 136
  
100         
 119 72 587 165 171*
    97 62 515 177
  
150         
 97 57 620 214 191*
    110 64 555 168
    122r 63 556 153
  
200         
 120 57 719 200 195*
    116 54 660 190
    131r 53 755 192
Positive Control 3-Methylcholanthrene 
2.5       
 94 50 1112 393 369*
    83 44 945 381
    103 53 1029 332

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination