Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02191-0002-0000-7 |
Chemical Name: | Fumaronitrile |
CASRN: | 764-42-1 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 546024_CA |
Study Result: | Weakly Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Weakly Positive |
Induced Rat Liver S9 | 1_S9 | Negative |
No Activation | 2 | Weakly Positive |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 7 | 0.035 | 3.0 | 0 | 0.000 | 0.0 | 7 | 0.035 | 3.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Fumaronitrile | 0.51 | 200 | 13 | 0.065 | 6.0 | 4 | 0.020 | 2.0 | 9 | 0.045 | 4.0 | 0 | 0.000 | 0.0 |
0.765 | 200 | 11 | 0.055 | 5.0 | 3 | 0.015 | 1.5 | 8 | 0.040 | 3.5 | 0 | 0.000 | 0.0 | ||
1.02 | 200 | 25 | 0.125 | 9.0 | 3 | 0.015 | 1.5 | 22 | 0.110 | 8.0 | 0 | 0.000 | 0.0 | ||
1.53 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.2 | 50 | 46 | 0.920 | 56.0 | 29 | 0.580 | 42.0 | 17 | 0.340 | 30.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 5 | 10 | 100 | 10.000 | 100.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 100 | 10.000 | 10.0 | |
Trend: | 2.236 | 1.161 | 2.078 | ||||||||||||
Probability: | 0.013 | 0.123 | 0.019 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 10 | 0.050 | 5.0 | 2 | 0.010 | 1.0 | 8 | 0.040 | 4.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Fumaronitrile | 0.505 | 200 | 8 | 0.040 | 3.5 | 4 | 0.020 | 2.0 | 4 | 0.020 | 1.5 | 0 | 0.000 | 0.0 |
1.52 | 200 | 5 | 0.025 | 2.5 | 2 | 0.010 | 1.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | ||
5.05 | 200 | 12 | 0.060 | 6.0 | 0 | 0.000 | 0.0 | 12 | 0.060 | 6.0 | 0 | 0.000 | 0.0 | ||
10.1 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 50 | 50 | 34 | 0.680 | 36.0 | 9 | 0.180 | 16.0 | 25 | 0.500 | 28.0 | 0 | 0.000 | 0.0 |
Trend: | 0.385 | -1.329 | 1.183 | ||||||||||||
Probability: | 0.350 | 0.908 | 0.118 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 6 | 0.030 | 3.0 | 1 | 0.005 | 0.5 | 5 | 0.025 | 2.5 | 0 | 0.000 | 0.0 |
Test Chemical: | Fumaronitrile | 0.101 | 200 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 |
0.303 | 200 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
0.505 | 200 | 19 | 0.095 | 9.0 | 1 | 0.005 | 0.5 | 18 | 0.090 | 8.5 | 0 | 0.000 | 0.0 | ||
1.01 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 1 | 200 | 103 | 0.515 | 34.0 | 43 | 0.215 | 17.0 | 50 | 0.250 | 21.0 | 10 | 0.050 | 1.0 |
Mitomycin-C | 5 | 50 | 70 | 1.400 | 68.0 | 21 | 0.420 | 30.0 | 39 | 0.780 | 58.0 | 10 | 0.200 | 1.0 | |
Trend: | 2.708 | -0.098 | 2.823 | ||||||||||||
Probability: | 0.003 | 0.539 | 0.002 |