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Study Information
Study Attribute Value
CEBS Accession Number: 002-02193-0001-0000-8
Chemical Name: Furan
CASRN: 110-00-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 950997_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Weakly Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 02/10/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 396 0.377 7.92 26.0 0.000
Test Chemical Furan 
1.6       
 50 1050 483 0.460 9.66 26.0 21.970 
5         
 50 1050 509 0.485 10.18 26.0 28.535 
16         
 50 1049 518 0.494 10.36 26.0 30.933 
50         
 50 1050 587 0.559 11.74 26.0 48.232 
160         
 6 125 70 0.560 11.67 26.0 48.485
Positive Control Mitomycin-C 
 0.0E-4    
 50 1051 516 0.491 10.32 26.0 30.179
Mitomycin-C 
 0.005     
 10 210 311 1.481 31.10 26.0 292.677
Trend: 6.029        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 04/21/1987    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 463 0.441 9.26 26.0 0.000
Test Chemical Furan 
5         
 50 1049 406 0.387 8.12 26.0 -12.227 
16         
 50 1050 471 0.449 9.42 26.0 1.728 
50         
 50 1051 519 0.494 10.38 26.0 11.988 
160         
 50 1049 591 0.563 11.82 26.0 27.767
Positive Control Mitomycin-C 
 0.0E-4    
 50 1046 589 0.563 11.78 26.0 27.700
Mitomycin-C 
 0.005     
 10 210 296 1.410 29.60 26.0 219.654
Trend: 5.271        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/10/1987    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 441 0.420 8.82 26.0 0.000
Test Chemical Furan 
16         
 50 1049 486 0.463 9.72 26.0 10.309 
50         
 50 1049 491 0.468 9.82 26.0 11.444 
160         
 50 1049 493 0.470 9.86 26.0 11.898 
500         
 50 1048 602 0.574 12.04 26.0 36.768 
1600         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.1       
 50 1049 550 0.524 11.00 26.0 24.835
Cyclophosphamide 
 0.6       
 10 210 207 0.986 20.70 26.0 134.694
Trend: 4.665        
Probability: 0.000