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Study Information
Study Attribute Value
CEBS Accession Number: 002-02193-0002-0000-9
Chemical Name: Furan
CASRN: 110-00-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 950997_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 07/01/1987    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Test Chemical: Furan 
160         
 200 19 0.095 8.0 7 0.035 3.5 12 0.060 5.5 0 0.000 0.0 
300         
 200 38 0.190 12.0 9 0.045 4.0 18 0.090 7.5 11 0.055 2.0 
500         
 200 35 0.175 11.5 10 0.050 5.0 15 0.075 7.0 10 0.050 1.0
Positive Control: Mitomycin-C 
 0.0625    
 200 39 0.195 16.0 14 0.070 6.0 25 0.125 11.5 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 20 0.400 36.0 14 0.280 28.0 6 0.120 10.0 0 0.000 0.0
Trend: 3.953 2.819 2.627  
Probability: 0.000 0.002 0.004  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/04/1987    Harvest Time: 13 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: Furan 
160         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
300         
 200 5 0.025 2.5 1 0.005 0.5 4 0.020 2.0 0 0.000 0.0 
500         
 200 15 0.075 7.5 12 0.060 6.0 3 0.015 1.5 0 0.000 0.0 
1000         
 93 32 0.344 24.7 8 0.086 8.6 24 0.258 20.4 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 44 0.220 21.0 10 0.050 5.0 34 0.170 16.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 30 0.600 44.0 11 0.220 20.0 19 0.380 34.0 0 0.000 0.0
Trend: 7.671 5.516 6.183  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 06/04/1987    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Furan 
100         
 200 7 0.035 3.5 1 0.005 0.5 6 0.030 3.0 0 0.000 0.0 
160         
 200 15 0.075 7.5 2 0.010 1.0 13 0.065 6.5 0 0.000 0.0 
300         
 200 42 0.210 17.0 8 0.040 4.0 34 0.170 13.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 37 0.185 18.0 17 0.085 8.5 20 0.100 10.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 28 0.560 38.0 11 0.220 18.0 17 0.340 26.0 0 0.000 0.0
Trend: 6.650 3.469 5.766  
Probability: 0.000 0.000 0.000