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Study Information
Study Attribute Value
CEBS Accession Number: 002-02193-0002-0000-9
Chemical Name: Furan
CASRN: 110-00-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 950997_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  Positive 

Trial #:1   Activation: No Activation    Date: 07/01/1987    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Test Chemical: Furan
160         
200 19 0.095 8.0 7 0.035 3.5 12 0.060 5.5 0 0.000 0.0
300         
200 38 0.190 12.0 9 0.045 4.0 18 0.090 7.5 11 0.055 2.0
500         
200 35 0.175 11.5 10 0.050 5.0 15 0.075 7.0 10 0.050 1.0
Positive Control: Mitomycin-C
 0.0625    
200 39 0.195 16.0 14 0.070 6.0 25 0.125 11.5 0 0.000 0.0
Mitomycin-C
 0.25      
50 20 0.400 36.0 14 0.280 28.0 6 0.120 10.0 0 0.000 0.0
Trend: 3.953 2.819 2.627  
Probability: 0.000 0.002 0.004  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/04/1987    Harvest Time: 13 hour(s)   Trial Call: Positive   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: Furan
160         
200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
300         
200 5 0.025 2.5 1 0.005 0.5 4 0.020 2.0 0 0.000 0.0
500         
200 15 0.075 7.5 12 0.060 6.0 3 0.015 1.5 0 0.000 0.0
1000         
93 32 0.344 24.7 8 0.086 8.6 24 0.258 20.4 0 0.000 0.0
Positive Control: Cyclophosphamide
2.5       
200 44 0.220 21.0 10 0.050 5.0 34 0.170 16.0 0 0.000 0.0
Cyclophosphamide
7.5       
50 30 0.600 44.0 11 0.220 20.0 19 0.380 34.0 0 0.000 0.0
Trend: 7.671 5.516 6.183  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 06/04/1987    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Furan
100         
200 7 0.035 3.5 1 0.005 0.5 6 0.030 3.0 0 0.000 0.0
160         
200 15 0.075 7.5 2 0.010 1.0 13 0.065 6.5 0 0.000 0.0
300         
200 42 0.210 17.0 8 0.040 4.0 34 0.170 13.5 0 0.000 0.0
Positive Control: Mitomycin-C
 0.0625    
200 37 0.185 18.0 17 0.085 8.5 20 0.100 10.0 0 0.000 0.0
Mitomycin-C
 0.25      
50 28 0.560 38.0 11 0.220 18.0 17 0.340 26.0 0 0.000 0.0
Trend: 6.650 3.469 5.766  
Probability: 0.000 0.000 0.000