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Study Information
Study Attribute Value
CEBS Accession Number: 002-02193-0010-0000-8
Chemical Name: Furan
CASRN: 110-00-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 048853
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Inconclusive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 73 100 97 44 40
    78 94 87 37
    75 105 94 42
    72 100 80 37
Test Chemical Furan 
125         
 73 88 74 34 35
    72 98 78 36
  
250         
 77 103 98 43 42
    68 86 86 42
  
500         
 70 88 78 37 32
    75 83 63 28
  
1000         
 67 76 72 36 36
    80 80 88 37
  
2000         
 66 68 90 45 54
    62 62 118 63
Positive Control Methyl Methane Sulfonate 
15         
 37 23 162 146 162*
    34 26 180 177

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 72 115 60 28 26
    92 107 97 35
    90 108 33 12
    55 71 45 27
Test Chemical Furan 
1400         
 83 103 61 24 27
    80 98 72 30
  
2000         
 88 76 57 22 31
    101 73 121 40
  
2600         
 77 52 227 99 76*
    78 51 125 54
  
3200         
 54 38 408 250 251*
    71 42 536 252
  
3800         
 51 6 1819 1181 1173*
    35 4 1235 1165
Positive Control Methyl Methane Sulfonate 
15         
 43 30 60 47 56*
    43 31 85 65
Methyl Methane Sulfonate 
250         
 69 81 213 103 118*
    80 97 318 133

Nonactivation Trial: 3 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 67 95 66 33 34
    62 107 69 37
    69 99 67 33
    64 99 63 33
Test Chemical Furan 
1139         
 56 67 137 82 66*
    76 86 115 51
  
1627         
 81 79 177 73 61*
    71 85 104 49
  
2116         
 72 71 334 154 143*
    67 60 264 131
  
2604         
 57 28 2021 1182 925*
    75 41 1494 668
  
3090         
 71 15 2433 1142 1512*
    45 13 2560 1882
Positive Control Methyl Methane Sulfonate 
15         
 38 29 79 70 78*
    38 34 99 86
Methyl Methane Sulfonate 
250         
 62 82 338 183 173*
    66 96 322 163

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination