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Study Information
Study Attribute Value
CEBS Accession Number: 002-02193-0011-0000-9
Chemical Name: Furan
CASRN: 110-00-9
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 635376_SCE
Study Result: Negative


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 11/17/86 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 4.47 ± 0.401
Test Chemical Furan 
87.5       
 4 4.84 ± 0.270
  
175         
 4 3.97 ± 0.750
  
350         
 4 4.25 ± 0.488
Positive Control Dimethylbenzanthracene 
100         
 4 9.15 ± 0.101


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 04/25/88 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 6.14 ± 1.059
Test Chemical Furan 
25         
 4 5.44 ± 0.678
  
50         
 4 5.88 ± 0.672
  
100         
 4 5.59 ± 1.490
Positive Control Dimethylbenzanthracene 
100         
 4 18.41 ± 1.091


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed