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Study Information
Study Attribute Value
CEBS Accession Number: 002-02193-0012-0000-0
Chemical Name: Furan
CASRN: 110-00-9
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 635376_CA
Study Result: Positive

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 11/24/86 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.2812
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 17.00 ± 4.93 0.0000
Test Chemical Furan 
87.5       
 8 1.00 ± 0.53 0.8777
  
175         
 8 1.00 ± 0.38 0.8777
  
350         
 8 2.25 ± 0.70 0.4032
Vehicle Control No Stressor 
 0         
 8 2.00 ± 1.00 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 04/12/88 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0000
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 27.50 ± 3.25 0.0000
Test Chemical Furan 
62.5       
 8 3.50 ± 1.18 0.0358
  
125         
 8 3.25 ± 0.84 0.0520
  
250         
 8 16.75 ± 1.89 0.0000
Vehicle Control No Stressor 
 0         
 7 1.43 ± 0.57 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 01/09/89 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.2673
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 7 24.86 ± 5.12 0.0000
Test Chemical Furan 
62.5       
 8 0.00 ± 0.00 0.9930
  
125         
 8 1.25 ± 0.75 0.6193
  
250         
 5 1.60 ± 0.98 0.4599
Vehicle Control No Stressor 
 0         
 8 1.50 ± 0.82 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 04/02/90 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0000
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 18.00 ± 1.60 0.0000
Test Chemical Furan 
62.5       
 8 3.50 ± 0.91 0.0608
  
125         
 8 3.00 ± 0.53 0.1228
  
250         
 8 19.50 ± 2.29 0.0000
Vehicle Control No Stressor 
 0         
 8 1.75 ± 0.59 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 01/07/92 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0000
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 28.00 ± 2.42 0.0000
Test Chemical Furan 
200         
 8 1.75 ± 0.96 0.2804
  
250         
 8 9.00 ± 1.65 0.0000
  
300         
 8 13.25 ± 2.53 0.0000
Vehicle Control No Stressor 
 0         
 8 1.25 ± 0.53 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed