Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Study Information
Study Attribute Value
CEBS Accession Number: 002-02193-0012-0000-0
Chemical Name: Furan
CASRN: 110-00-9
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 635376_CA
Study Result: Positive

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 11/24/86 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.2812
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 17.00 ± 4.93 0.0000
Test Chemical Furan 
87.5       
 8 1.00 ± 0.53 0.8777
  
175         
 8 1.00 ± 0.38 0.8777
  
350         
 8 2.25 ± 0.70 0.4032
Vehicle Control No Stressor 
 0         
 8 2.00 ± 1.00 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 04/12/88 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0000
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 27.50 ± 3.25 0.0000
Test Chemical Furan 
62.5       
 8 3.50 ± 1.18 0.0358
  
125         
 8 3.25 ± 0.84 0.0520
  
250         
 8 16.75 ± 1.89 0.0000
Vehicle Control No Stressor 
 0         
 7 1.43 ± 0.57 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 01/09/89 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.2673
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 7 24.86 ± 5.12 0.0000
Test Chemical Furan 
62.5       
 8 0.00 ± 0.00 0.9930
  
125         
 8 1.25 ± 0.75 0.6193
  
250         
 5 1.60 ± 0.98 0.4599
Vehicle Control No Stressor 
 0         
 8 1.50 ± 0.82 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 04/02/90 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0000
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 18.00 ± 1.60 0.0000
Test Chemical Furan 
62.5       
 8 3.50 ± 0.91 0.0608
  
125         
 8 3.00 ± 0.53 0.1228
  
250         
 8 19.50 ± 2.29 0.0000
Vehicle Control No Stressor 
 0         
 8 1.75 ± 0.59 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 01/07/92 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0000
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 28.00 ± 2.42 0.0000
Test Chemical Furan 
200         
 8 1.75 ± 0.96 0.2804
  
250         
 8 9.00 ± 1.65 0.0000
  
300         
 8 13.25 ± 2.53 0.0000
Vehicle Control No Stressor 
 0         
 8 1.25 ± 0.53 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed