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Study Information
Study Attribute Value
CEBS Accession Number: 002-02194-0001-0000-9
Chemical Name: Furfural
CASRN: 98-01-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 384163_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 01/20/1983    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1046 490 0.468 9.80 25.8 0.000
Test Chemical Furfural
11.7       
50 1048 640 0.611 12.80 25.8 30.363
38.9       
50 1038 874 0.842 17.48 35.8 79.742
117         
50 1037 851 0.821 17.02 35.8 75.181
389         
0 0 0 0.000 0.00 35.8 N/A
Positive Control Mitomycin-C
 0.001     
50 1048 762 0.727 15.24 25.8 55.213
Mitomycin-C
 0.01      
5 104 261 2.510 52.20 25.8 435.726
Trend: 11.312        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/20/1983    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1048 473 0.451 9.46 25.8 0.000
Test Chemical Furfural
117         
50 1046 568 0.543 11.36 25.8 20.314
389         
50 1046 686 0.656 13.72 25.8 45.309
1170         
50 1044 1252 1.199 25.04 35.8 165.708
3890         
0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide
 0.3       
50 1053 777 0.738 15.54 25.8 63.491
Cyclophosphamide
2         
5 105 212 2.019 42.40 25.8 347.349
Trend: 20.031        
Probability: 0.000