COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02194-0001-0000-9
Chemical Name: Furfural
CASRN: 98-01-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 384163_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 01/20/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 490 0.468 9.80 25.8 0.000
Test Chemical Furfural 
11.7       
 50 1048 640 0.611 12.80 25.8 30.363 
38.9       
 50 1038 874 0.842 17.48 35.8 79.742 
117         
 50 1037 851 0.821 17.02 35.8 75.181 
389         
 0 0 0 0.000 0.00 35.8 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1048 762 0.727 15.24 25.8 55.213
Mitomycin-C 
 0.01      
 5 104 261 2.510 52.20 25.8 435.726
Trend: 11.312        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/20/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 473 0.451 9.46 25.8 0.000
Test Chemical Furfural 
117         
 50 1046 568 0.543 11.36 25.8 20.314 
389         
 50 1046 686 0.656 13.72 25.8 45.309 
1170         
 50 1044 1252 1.199 25.04 35.8 165.708 
3890         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1053 777 0.738 15.54 25.8 63.491
Cyclophosphamide 
2         
 5 105 212 2.019 42.40 25.8 347.349
Trend: 20.031        
Probability: 0.000