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Study Information
Study Attribute Value
CEBS Accession Number: 002-02194-0002-0000-0
Chemical Name: Furfural
CASRN: 98-01-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 384163_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive* 

Trial #:1   Activation: No Activation    Date: 02/03/1983    Harvest Time: 23.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
100 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0
Dimethyl Sulfoxide
0         
100 3 0.030 3.0 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0
Test Chemical: Furfural
200         
100 7 0.070 5.0 1 0.010 1.0 4 0.040 2.0 2 0.020 2.0
300         
100 7 0.070 6.0 0 0.000 0.0 7 0.070 6.0 0 0.000 0.0
401         
100 24 0.240 15.0 6 0.060 6.0 6 0.060 5.0 12 0.120 3.0
501         
100 23 0.230 22.0 13 0.130 13.0 10 0.100 9.0 0 0.000 0.0
Positive Control: Mitomycin-C
 0.05      
50 26 0.520 28.0 9 0.180 16.0 7 0.140 12.0 10 0.200 2.0
Trend: 4.854 3.885 3.239  
Probability: 0.000 0.000 0.001  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 02/03/1983    Harvest Time: 22 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
100 4 0.040 4.0 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0
Dimethyl Sulfoxide
0         
100 5 0.050 5.0 3 0.030 3.0 1 0.010 1.0 1 0.010 1.0
Test Chemical: Furfural
500         
100 4 0.040 4.0 1 0.010 1.0 1 0.010 1.0 2 0.020 2.0
760         
100 6 0.060 6.0 3 0.030 3.0 3 0.030 3.0 0 0.000 0.0
1000         
100 118 1.180 54.0 75 0.750 45.0 31 0.310 23.0 12 0.120 3.0
1230         
0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide
10         
50 12 0.240 22.0 4 0.080 8.0 8 0.160 16.0 0 0.000 0.0
Trend: 8.486 8.190 5.767  
Probability: 0.000 0.000 0.000