Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02194-0015-0000-4 |
Chemical Name: | Furfural |
CASRN: | 98-01-1 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Mutagenicity |
NTP Study ID: | 686415 |
Study Result: | Positive |
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 | 83 | 96 | 145 | 58 | 64 |
60 | 83 | 153 | 86 | ||||
57 | 121 | 84 | 49 | ||||
43r | 70 | 83 | 65 | ||||
Test Chemical | Furfural | 25 | 72 | 107 | 126 | 58 | 53 |
71 | 137 | 102 | 48 | ||||
50 | 69 | 90 | 128 | 62 | 59 | ||
74 | 92 | 127 | 57 | ||||
100 | 34 | 45 | 121 | 119 | 100 | ||
52 | 75 | 129 | 82 | ||||
200 | 48 | 28 | 215 | 149 | 133* | ||
55 | 35 | 195 | 117 | ||||
400 | 24# | 8 | 627 | 859 | 721* | ||
35 | 11 | 603 | 583 | ||||
800 | |||||||
Positive Control | Methyl Methane Sulfonate | 15 | 25 | 14 | 440 | 591 | 624* |
16 | 8 | 312 | 657 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 | 69 | 88 | 201 | 98 | 95 |
88 | 114 | 224 | 85 | ||||
68 | 98 | 210 | 103 | ||||
95 | 100 | 261 | 92 | ||||
Test Chemical | Furfural | 25 | 86 | 114 | 219 | 85 | 95 |
76 | 95 | 239 | 105 | ||||
50 | 89 | 84 | 298 | 112 | 96 | ||
84 | 88 | 202 | 80 | ||||
100 | 81 | 55 | 272 | 112 | 111 | ||
106 | 55 | 352 | 111 | ||||
200 | 56 | 28 | 404 | 239 | 223* | ||
74 | 26 | 457 | 207 | ||||
400 | |||||||
Positive Control | Methyl Methane Sulfonate | 15 | 25 | 16 | 404 | 532 | 529* |
46 | 23 | 726 | 526 |
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination