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Study Information
Study Attribute Value
CEBS Accession Number: 002-02194-0015-0000-4
Chemical Name: Furfural
CASRN: 98-01-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 686415
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 83 96 145 58 64
    60 83 153 86
    57 121 84 49
    43r 70 83 65
Test Chemical Furfural 
25         
 72 107 126 58 53
    71 137 102 48
  
50         
 69 90 128 62 59
    74 92 127 57
  
100         
 34 45 121 119 100
    52 75 129 82
  
200         
 48 28 215 149 133*
    55 35 195 117
  
400         
 24# 8 627 859 721*
    35 11 603 583
  
800         
   
Positive Control Methyl Methane Sulfonate 
15         
 25 14 440 591 624*
    16 8 312 657

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 69 88 201 98 95
    88 114 224 85
    68 98 210 103
    95 100 261 92
Test Chemical Furfural 
25         
 86 114 219 85 95
    76 95 239 105
  
50         
 89 84 298 112 96
    84 88 202 80
  
100         
 81 55 272 112 111
    106 55 352 111
  
200         
 56 28 404 239 223*
    74 26 457 207
  
400         
   
Positive Control Methyl Methane Sulfonate 
15         
 25 16 404 532 529*
    46 23 726 526

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination