Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02194-0015-0000-4
Chemical Name:	Furfural
CASRN:	98-01-1
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	686415
Study Result:	Positive

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Water	0	83	96	145	58	64
			60	83	153	86
			57	121	84	49
			43r	70	83	65
Test Chemical	Furfural	25	72	107	126	58	53
			71	137	102	48	53
		50	69	90	128	62	59
			74	92	127	57	59
		100	34	45	121	119	100
			52	75	129	82	100
		200	48	28	215	149	133*
			55	35	195	117	133*
		400	24#	8	627	859	721*
			35	11	603	583	721*
		800

Positive Control	Methyl Methane Sulfonate	15	25	14	440	591	624*
Positive Control			16	8	312	657	624*

Nonactivation Trial: 2 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Water	0	69	88	201	98	95
			88	114	224	85
			68	98	210	103
			95	100	261	92
Test Chemical	Furfural	25	86	114	219	85	95
			76	95	239	105	95
		50	89	84	298	112	96
			84	88	202	80	96
		100	81	55	272	112	111
			106	55	352	111	111
		200	56	28	404	239	223*
			74	26	457	207	223*
		400

Positive Control	Methyl Methane Sulfonate	15	25	16	404	532	529*
Positive Control			46	23	726	526	529*

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination