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Study Information
Study Attribute Value
CEBS Accession Number: 002-02196-0001-0000-1
Chemical Name: Furfuryl alcohol
CASRN: 98-00-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 799233_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 03/17/1987    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 422 0.404 8.44 26.0 0.000
Test Chemical Furfuryl alcohol 
16         
 50 1050 444 0.423 8.88 26.0 4.712 
50         
 50 1051 451 0.429 9.02 26.0 6.262 
160         
 50 1049 416 0.397 8.32 26.0 -1.798 
500         
 50 1051 572 0.544 11.44 26.0 34.771
Positive Control Mitomycin-C 
 0.0E-4    
 50 1046 558 0.533 11.16 26.0 32.101
Mitomycin-C 
 0.005     
 10 210 384 1.829 38.40 26.0 352.810
Trend: 3.930        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 06/30/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 459 0.438 9.18 26.0 0.000
Test Chemical Furfuryl alcohol 
16         
 50 1044 435 0.417 8.70 26.0 -4.775 
50         
 50 1048 436 0.416 8.72 26.0 -4.920 
160         
 50 1046 555 0.531 11.10 26.0 21.262 
500         
 3 61 41 0.672 13.67 26.0 53.609 
500         
 50 1051 587 0.559 11.74 31.0 27.643
Positive Control Mitomycin-C 
 0.0E-4    
 50 1046 551 0.527 11.02 26.0 20.388
Mitomycin-C 
 0.005     
 10 209 259 1.239 25.90 26.0 183.215
Trend: 5.717        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/17/1987    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 452 0.430 9.04 26.0 0.000
Test Chemical Furfuryl alcohol 
16         
 50 1049 400 0.381 8.00 26.0 -11.420 
50         
 50 1050 458 0.436 9.16 26.0 1.327 
160         
 50 1050 482 0.459 9.64 26.0 6.637 
500         
 50 1050 512 0.488 10.24 26.0 13.274
Positive Control Cyclophosphamide 
 0.1       
 50 1051 567 0.539 11.34 26.0 25.323
Cyclophosphamide 
 0.6       
 10 210 202 0.962 20.20 26.0 123.451
Trend: 2.970        
Probability: 0.001