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Study Information
Study Attribute Value
CEBS Accession Number: 002-02196-0002-0000-2
Chemical Name: Furfuryl alcohol
CASRN: 98-00-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 799233_CA
Study Result: Equivocal

Study Result: Equivocal
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Negative 

Trial #:1   Activation: No Activation    Date: 07/01/1987    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Test Chemical: Furfuryl alcohol 
160         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
300         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
500         
 200 7 0.035 3.5 3 0.015 1.5 4 0.020 2.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 39 0.195 16.0 14 0.070 6.0 25 0.125 11.5 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 20 0.400 36.0 14 0.280 28.0 6 0.120 10.0 0 0.000 0.0
Trend: 1.317 2.263 0.365  
Probability: 0.094 0.012 0.358  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 07/01/1987    Harvest Time: 13 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Furfuryl alcohol 
300         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0 
500         
 200 6 0.030 3.0 2 0.010 1.0 4 0.020 2.0 0 0.000 0.0 
1000         
 200 11 0.055 5.0 3 0.015 1.5 8 0.040 4.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 35 0.175 14.5 10 0.050 5.0 25 0.125 10.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 21 0.420 32.0 9 0.180 16.0 12 0.240 22.0 0 0.000 0.0
Trend: 3.831 1.830 3.652  
Probability: 0.000 0.034 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 02/04/1988    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Furfuryl alcohol 
500         
 200 4 0.020 1.5 2 0.010 1.0 2 0.010 0.5 0 0.000 0.0 
1000         
 200 6 0.030 3.0 1 0.005 0.5 5 0.025 2.5 0 0.000 0.0 
1600         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 22 0.110 10.5 3 0.015 1.5 19 0.095 9.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 18 0.360 32.0 2 0.040 4.0 16 0.320 28.0 0 0.000 0.0
Trend: 0.564 0.439 0.373  
Probability: 0.286 0.330 0.354