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Study Information
Study Attribute Value
CEBS Accession Number: 002-02202-0001-0000-9
Chemical Name: Geranyl acetate
CASRN: 105-87-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 076096_SCE
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Weakly Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 05/10/1982    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 515 0.493 10.30 25.5 0.000
Test Chemical Geranyl acetate 
45         
 50 1050 554 0.528 11.08 25.5 7.061 
60         
 50 1046 559 0.534 11.18 25.5 8.440 
75         
 50 1038 660 0.636 13.20 34.5 29.020
Positive Control Mitomycin-C 
 0.005     
 25 525 711 1.354 28.44 25.5 174.802
Trend: 4.157        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 06/03/1982    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1051 521 0.496 10.42 25.8 0.000
Test Chemical Geranyl acetate 
60         
 50 1060 571 0.539 11.42 25.8 8.666 
70         
 50 1053 633 0.601 12.66 35.5 21.266 
80         
 50 1033 603 0.584 12.06 35.5 17.756 
90         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.005     
 25 523 792 1.514 31.68 25.8 205.484
Trend: 3.206        
Probability: 0.001        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/10/1982    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1043 489 0.469 9.78 25.5 0.000
Test Chemical Geranyl acetate 
100         
 50 1045 484 0.463 9.68 25.5 -1.212 
150         
 50 1038 556 0.536 11.12 25.5 14.249 
200         
 0 0 0 0.000 0.00 25.5 N/A 
254         
 0 0 0 0.000 0.00 25.5 N/A 
299         
 50 1035 722 0.698 14.44 34.5 48.790
Positive Control Cyclophosphamide 
1.5       
 25 527 1147 2.176 45.88 25.5 364.225
Trend: 8.017        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 06/22/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1054 541 0.513 10.82 26.8 0.000
Test Chemical Geranyl acetate 
50         
 50 1047 532 0.508 10.64 26.8 -1.006 
100         
 50 1053 522 0.496 10.44 26.8 -3.420 
150         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
1.5       
 25 531 616 1.160 24.64 26.8 126.011
Trend: -0.574        
Probability: 0.717