Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02202-0002-0000-0 |
Chemical Name: | Geranyl acetate |
CASRN: | 105-87-3 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 076096_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 100 | 5 | 0.050 | 4.0 | 4 | 0.040 | 3.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Geranyl acetate | 60 | 100 | 4 | 0.040 | 4.0 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
80 | 100 | 3 | 0.030 | 3.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | ||
100 | 100 | 3 | 0.030 | 3.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | ||
Positive Control: | Mitomycin-C | 0.062 | 50 | 12 | 0.240 | 22.0 | 4 | 0.080 | 8.0 | 7 | 0.140 | 12.0 | 1 | 0.020 | 2.0 |
Trend: | -0.495 | -1.148 | -0.040 | ||||||||||||
Probability: | 0.690 | 0.875 | 0.516 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 100 | 6 | 0.060 | 6.0 | 2 | 0.020 | 2.0 | 2 | 0.020 | 2.0 | 2 | 0.020 | 2.0 | |
Test Chemical: | Geranyl acetate | 50 | 100 | 6 | 0.060 | 5.0 | 2 | 0.020 | 2.0 | 3 | 0.030 | 3.0 | 1 | 0.010 | 1.0 |
100 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
150 | 100 | 8 | 0.080 | 5.0 | 2 | 0.020 | 2.0 | 5 | 0.050 | 3.0 | 1 | 0.010 | 1.0 | ||
Positive Control: | Cyclophosphamide | 50 | 50 | 19 | 0.380 | 20.0 | 10 | 0.200 | 16.0 | 9 | 0.180 | 12.0 | 0 | 0.000 | 0.0 |
Trend: | -0.936 | -0.497 | 0.051 | ||||||||||||
Probability: | 0.825 | 0.690 | 0.480 |