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Study Information
Study Attribute Value
CEBS Accession Number: 002-02208-0001-0000-5
Chemical Name: Glutaraldehyde
CASRN: 111-30-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 004326_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 06/10/1981    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1026 390 0.380 7.80 25.5 0.000
Test Chemical Glutaraldehyde 
 0.36      
 50 1031 475 0.461 9.50 25.5 21.204 
1.08      
 50 1034 400 0.387 8.00 25.5 1.771 
3.6       
 50 1028 539 0.524 10.78 25.5 37.936 
10.8       
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Triethylenemelamine 
15         
 50 1010 2079 2.058 41.58 25.5 441.522
Trend: 3.947        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/09/1981    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1035 477 0.461 9.54 25.5 0.000
Test Chemical Glutaraldehyde 
1         
 50 1046 501 0.479 10.02 25.5 3.927 
3.6       
 50 1045 535 0.512 10.70 25.5 11.086 
10.8       
 50 1035 713 0.689 14.26 25.5 49.476
Positive Control Cyclophosphamide 
1.5       
 50 1023 1348 1.318 26.96 25.5 185.915
Trend: 6.961        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 07/02/1981    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1026 394 0.384 7.88 26.0 0.000
Test Chemical Glutaraldehyde 
10         
 50 1028 451 0.439 9.02 26.0 14.244 
12.5       
 50 1019 560 0.550 11.20 26.0 43.108 
15         
 50 1025 652 0.636 13.04 26.0 65.644
Positive Control Cyclophosphamide 
1.5       
 50 1052 1691 1.607 33.82 26.0 318.581
Trend: 8.765        
Probability: 0.000