COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02208-0003-0000-7
Chemical Name: Glutaraldehyde
CASRN: 111-30-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 146021_SCE
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 09/23/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 524 0.499 10.48 26.0 0.000
Test Chemical Glutaraldehyde 
 0.5       
 50 1050 545 0.519 10.90 26.0 4.008 
1.6       
 50 1049 483 0.460 9.66 26.0 -7.737 
5         
 50 1048 531 0.507 10.62 26.0 1.529 
16         
 25 524 321 0.613 12.84 26.0 22.753
Positive Control Triethylenemelamine 
 0.015     
 50 1050 1437 1.369 28.74 26.0 174.237
Trend: 1.807        
Probability: 0.035        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/23/1981    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 100 2097 915 0.436 9.15 26.0 0.000
Test Chemical Glutaraldehyde 
1.6       
 50 1048 484 0.462 9.68 26.0 5.843 
5         
 50 1047 484 0.462 9.68 26.0 5.944 
16         
 100 2092 1167 0.558 11.67 26.0 27.846
Positive Control Cyclophosphamide 
1         
 100 2095 2593 1.238 25.93 26.0 183.659
Trend: 5.502        
Probability: 0.000