Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02208-0023-0000-9
Chemical Name:	Glutaraldehyde
CASRN:	111-30-8
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	558174
Study Result:	Positive

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Water	0	77	111	41	18	29
			58	102	55	31
			71	89	68	32
			68	98	68	33
Test Chemical	Glutaraldehyde	0.5	64#	106	105	55	39
			68#	153	48	23	39
		1	83	154	80	32	40
			62#	96	87	47	40
		2	80	199	67	28	59*
			44	71	120	91	59*
		4	75	128	97	43	45
			69#	100	97.5	47	45
		8	67	22	285	142	206*
			29	26	236	270	206*
		16

Positive Control	Ethyl Methane Sulfonate	250	80#	84	352.5	147	148*
Positive Control			70#	91	312	149	148*

Nonactivation Trial: 2 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Water	0	59	110	66	38	39
			48r	66	81	57
			74	102	79	36
			70	88	95	45
Test Chemical	Glutaraldehyde	0.5	80	93	88	37	47
			92	88	160	58	47
		1	66	90	57	29	32
			86	98	92	36	32
		2	64	90	76	40	43
			79	87	107	45	43
		4	72	69	89	41	56
			89	64	187	70	56
		8	27	5	283	352	481*
			21	2	385	611	481*
		16

Positive Control	Ethyl Methane Sulfonate	250	63	62	615	325	324*
Positive Control			75	55	725	324	324*

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination