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Study Information
Study Attribute Value
CEBS Accession Number: 002-02208-0024-0000-0
Chemical Name: Glutaraldehyde
CASRN: 111-30-8
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 212368_CA
Study Result: Positive

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 07/08/91 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.2784
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 1.75 ± 0.96 0.0039
Test Chemical Glutaraldehyde 
15         
 8 1.50 ± 0.73 0.0070
  
30         
 8 0.75 ± 0.53 0.0413
  
60         
 8 0.75 ± 0.37 0.0413
Vehicle Control No Stressor 
 0         
 8 0.00 ± 0.00 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 09/10/91 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0000
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 6.50 ± 2.06 0.0000
Test Chemical Glutaraldehyde 
15         
 8 1.50 ± 0.63 0.0776
  
30         
 8 3.25 ± 1.13 0.0021
  
50         
 8 5.25 ± 2.17 0.0000
  
60         
 8 5.75 ± 1.28 0.0000
Vehicle Control No Stressor 
 0         
 8 0.50 ± 0.33 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 11/02/93 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0027
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
2         
 8 6.75 ± 1.85 0.0000
Test Chemical Glutaraldehyde 
15         
 8 0.75 ± 0.53 0.3269
  
30         
 8 0.75 ± 0.37 0.3269
  
50         
 8 0.75 ± 0.53 0.3269
  
60         
 8 3.00 ± 1.07 0.0035
Vehicle Control No Stressor 
 0         
 8 0.50 ± 0.33 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed