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Study Information
Study Attribute Value
CEBS Accession Number: 002-02212-0001-0000-0
Chemical Name: Glycidol
CASRN: 556-52-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 536149_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 01/10/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1015 432 0.426 8.64 25.8 0.000
Test Chemical Glycidol 
1.11      
 10 206 590 2.864 59.00 25.8 572.926 
3.69      
 10 205 856 4.176 85.60 25.8 881.075 
11.07      
 5 104 868 8.346 173.60 30.8 1860.960 
36.9       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.005     
 50 1018 669 0.657 13.38 25.8 54.405
Mitomycin-C 
 0.01      
 5 102 192 1.882 38.40 25.8 342.266
Trend: 64.495        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 01/31/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1036 453 0.437 9.06 25.6 0.000
Test Chemical Glycidol 
10.1       
 10 207 883 4.266 88.30 25.6 875.555 
12.5       
 5 105 572 5.448 114.40 25.6 1145.857 
15         
 5 102 683 6.696 136.60 31.8 1431.377
Positive Control Mitomycin-C 
 0.0015    
 50 1020 780 0.765 15.60 25.6 74.886
Mitomycin-C 
 0.01      
 5 105 220 2.095 44.00 25.6 379.176
Trend: 60.527        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/10/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1038 538 0.518 10.76 25.8 0.000
Test Chemical Glycidol 
11.07      
 25 513 896 1.747 35.84 25.8 236.981 
36.9       
 25 510 1754 3.439 70.16 30.8 563.551 
110.71      
 25 511 2652 5.190 106.08 30.8 901.308 
369.02      
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1021 855 0.837 17.10 25.8 61.568
Cyclophosphamide 
2         
 5 108 273 2.528 54.60 25.8 387.701
Trend: 60.536        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 01/31/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1032 606 0.587 12.12 25.6 0.000
Test Chemical Glycidol 
100.5       
 10 206 860 4.175 86.00 31.8 610.949 
124.5       
 5 107 596 5.570 119.20 31.8 848.570 
150         
 5 106 599 5.651 119.80 31.8 862.339
Positive Control Cyclophosphamide 
 0.4       
 50 1024 739 0.722 14.78 25.6 22.900
Cyclophosphamide 
2         
 5 104 142 1.365 28.40 25.6 132.521
Trend: 53.013        
Probability: 0.000