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Study Information
Study Attribute Value
CEBS Accession Number: 002-02212-0002-0000-1
Chemical Name: Glycidol
CASRN: 556-52-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 536149_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 03/01/1984    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Medium 
0         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Glycidol 
50.3       
 25 46 1.840 80.0 19 0.760 52.0 17 0.680 48.0 10 0.400 4.0 
75         
 25 88 3.520 84.0 13 0.520 32.0 15 0.600 40.0 60 2.400 24.0 
100         
 25 120 4.800 84.0 18 0.720 44.0 22 0.880 48.0 80 3.200 32.0
Positive Control: Mitomycin-C 
 0.025     
 100 12 0.120 10.0 2 0.020 2.0 10 0.100 8.0 0 0.000 0.0
Mitomycin-C 
 0.062     
 25 10 0.400 24.0 3 0.120 12.0 7 0.280 16.0 0 0.000 0.0
Trend: 9.688 5.546 6.380  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 02/16/1984    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 7 0.070 5.0 1 0.010 1.0 6 0.060 4.0 0 0.000 0.0
Medium 
0         
 100 7 0.070 5.0 0 0.000 0.0 7 0.070 5.0 0 0.000 0.0
Test Chemical: Glycidol 
198.7       
 25 44 1.760 60.0 19 0.760 40.0 23 0.920 52.0 2 0.080 4.0 
301.2       
 25 163 6.520 96.0 20 0.800 44.0 33 1.320 48.0 110 4.400 44.0 
400.7       
 25 172 6.880 100.0 44 1.760 64.0 28 1.120 40.0 100 4.000 40.0 
502.1       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 100 20 0.200 13.0 3 0.030 3.0 17 0.170 11.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 17 0.680 44.0 8 0.320 28.0 9 0.360 32.0 0 0.000 0.0
Trend: 10.867 7.870 5.190  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 02/16/1984    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Medium 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Glycidol 
12.5       
 100 16 0.160 12.0 5 0.050 5.0 11 0.110 10.0 0 0.000 0.0 
24.8       
 25 19 0.760 44.0 6 0.240 20.0 13 0.520 32.0 0 0.000 0.0 
49.9       
 25 52 2.080 80.0 18 0.720 36.0 34 1.360 62.0 0 0.000 0.0 
75.2       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.025     
 100 18 0.180 16.0 7 0.070 6.0 11 0.110 10.0 0 0.000 0.0
Mitomycin-C 
 0.0625    
 25 12 0.480 32.0 2 0.080 8.0 10 0.400 28.0 0 0.000 0.0
Trend: 9.703 6.382 8.160  
Probability: 0.000 0.000 0.000