Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02212-0021-0000-2
Chemical Name:	Glycidol
CASRN:	556-52-5
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	036941
Study Result:	Positive

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
		Conc. uL/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Water	0	111	130	132	40	38
			84	130	102	41
			93	90	80	29
			100	49	126	42
Test Chemical	Glycidol	0.005	67	66	444	220	215*
			63#	54	414	221
			79	73	490	206
		0.01	67	31	774	387	416*
			63	24	845	446	416*
		0.02	31	11	689	745
		0.03	13	1	442	1163	1113*
			13	1	405	1080
			17	3	542	1095
		0.04


Positive Control	Methyl Methane Sulfonate	5	104	100	283	90	125*
			110	92	427	130
			94	90	440	156

Nonactivation Trial: 2 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Water	0	137r	112	102	25	28
			88	95	81	31
			117	103	79	23
			107	102	100	31
Test Chemical	Glycidol	0.313	69	67	57	28	34
			69	60	81	39
			87	64	90	35
		0.625	105	85	92	29	33
			91	71	98	36
			115	71	112	33
		1.25	88	73	167	63	59*
			110	71	174	53
			91	74	164	60
		2.5	99	55	334	113	101*
			90	65	281	105
			103	71	264	86
		5	96	45	590	205	208*
			81	52	541	223
			74	50	437	198
		10	91	45	782	286	386*
			57	37	681	396
			55	23	783	476
Positive Control	Methyl Methane Sulfonate	5	75	42	457	203	178*
			96	72	467	163
			79	57	401	170

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination