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Study Information
Study Attribute Value
CEBS Accession Number: 002-02212-0021-0000-2
Chemical Name: Glycidol
CASRN: 556-52-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 036941
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
uL/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 111 130 132 40 38
    84 130 102 41
    93 90 80 29
    100 49 126 42
Test Chemical Glycidol 
 0.005     
 67 66 444 220 215*
    63# 54 414 221
    79 73 490 206
  
 0.01      
 67 31 774 387 416*
    63 24 845 446
  
 0.02      
 31 11 689 745
  
 0.03      
 13 1 442 1163 1113*
    13 1 405 1080
    17 3 542 1095
  
 0.04      
   
   
Positive Control Methyl Methane Sulfonate 
5         
 104 100 283 90 125*
    110 92 427 130
    94 90 440 156

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 137r 112 102 25 28
    88 95 81 31
    117 103 79 23
    107 102 100 31
Test Chemical Glycidol 
 0.313     
 69 67 57 28 34
    69 60 81 39
    87 64 90 35
  
 0.625     
 105 85 92 29 33
    91 71 98 36
    115 71 112 33
  
1.25      
 88 73 167 63 59*
    110 71 174 53
    91 74 164 60
  
2.5       
 99 55 334 113 101*
    90 65 281 105
    103 71 264 86
  
5         
 96 45 590 205 208*
    81 52 541 223
    74 50 437 198
  
10         
 91 45 782 286 386*
    57 37 681 396
    55 23 783 476
Positive Control Methyl Methane Sulfonate 
5         
 75 42 457 203 178*
    96 72 467 163
    79 57 401 170

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination