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Study Information
Study Attribute Value
CEBS Accession Number: 002-02229-0001-0000-8
Chemical Name: HC blue 1
CASRN: 2784-94-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 788910_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 05/09/1985    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 385 0.368 7.70 26.0 0.000
Test Chemical HC blue 1 
11.9       
 50 1048 353 0.337 7.06 26.0 -8.574 
39.6       
 50 1049 396 0.378 7.92 26.0 2.465 
119         
 50 1041 485 0.466 9.70 26.0 26.458
Positive Control Mitomycin-C 
 0.0015    
 50 1052 563 0.535 11.26 26.0 45.261
Mitomycin-C 
 0.01      
 10 210 292 1.390 29.20 26.0 277.415
Trend: 3.836        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 06/04/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 355 0.340 7.10 27.0 0.000
Test Chemical HC blue 1 
135         
 50 1043 570 0.547 11.40 26.5 60.871 
180         
 50 1047 648 0.619 12.96 26.5 82.187 
225         
 50 1043 710 0.681 14.20 30.5 100.384
Positive Control Mitomycin-C 
 0.0015    
 50 1045 505 0.483 10.10 27.0 42.254
Mitomycin-C 
 0.01      
 10 211 254 1.204 25.40 27.0 254.356
Trend: 10.742        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/09/1985    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1051 377 0.359 7.54 26.0 0.000
Test Chemical HC blue 1 
39.6       
 50 1052 448 0.426 8.96 26.0 18.720 
119         
 50 1049 458 0.437 9.16 26.0 21.717 
396         
 50 1049 434 0.414 8.68 26.0 15.339
Positive Control Cyclophosphamide 
 0.4       
 50 1048 752 0.718 15.04 26.0 100.040
Cyclophosphamide 
2.5       
 10 208 443 2.130 44.30 26.0 493.747
Trend: 1.974        
Probability: 0.024