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Study Information
Study Attribute Value
CEBS Accession Number: 002-02229-0011-0000-9
Chemical Name: HC blue 1
CASRN: 2784-94-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 069905_SCE


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 01/14/86 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Dimethyl Sulfoxide 
 0         
 4 4.09 ± 0.443
Test Chemical HC blue 1 
125         
 4 4.18 ± 0.280
  
250         
 4 4.79 ± 0.353
  
500         
 4 6.43 ± 0.757
Positive Control Dimethylbenzanthracene 
2.5       
 4 10.65 ± 0.795


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 11/12/86 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Dimethyl Sulfoxide 
 0         
 4 3.76 ± 0.164
Test Chemical HC blue 1 
375         
 4 5.02 ± 0.128
  
500         
 4 6.56 ± 0.921


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed