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Study Information
Study Attribute Value
CEBS Accession Number: 002-02229-0012-0000-0
Chemical Name: HC blue 1
CASRN: 2784-94-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 069905_CA
Study Result: Positive

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 01/23/86 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0000
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 11.25 ± 2.00 0.0000
Test Chemical HC blue 1 
125         
 8 1.00 ± 0.38 0.0892
  
250         
 8 0.75 ± 0.37 0.1580
  
500         
 8 5.50 ± 1.30 0.0000
Vehicle Control No Stressor 
 0         
 8 0.25 ± 0.25 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 12/17/86 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0048
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 9.50 ± 1.72 0.0000
Test Chemical HC blue 1 
375         
 8 2.75 ± 0.75 0.0018
  
500         
 8 2.25 ± 0.70 0.0055
Vehicle Control No Stressor 
 0         
 8 0.25 ± 0.25 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 01/12/88 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0152
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 34.75 ± 1.92 0.0000
Test Chemical HC blue 1 
125         
 8 2.50 ± 0.50 0.0529
  
250         
 8 3.00 ± 0.93 0.0217
  
500         
 8 3.50 ± 1.18 0.0086
Vehicle Control No Stressor 
 0         
 8 1.00 ± 0.53 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed