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Study Information
Study Attribute Value
CEBS Accession Number: 002-02230-0011-0000-1
Chemical Name: HC blue 2
CASRN: 33229-34-4
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 908121_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 02/12/86 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0408
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 10.50 ± 1.72 0.0000
Test Chemical HC blue 2 
375         
 8 0.50 ± 0.33 0.5000
  
750         
 8 0.75 ± 0.53 0.3269
  
1500         
 8 1.50 ± 0.63 0.0776
Vehicle Control No Stressor 
 0         
 8 0.50 ± 0.50 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 05/27/87 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0851
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 30.25 ± 2.02 0.0000
Test Chemical HC blue 2 
375         
 8 0.50 ± 0.50 0.5000
  
750         
 8 0.75 ± 0.37 0.3269
  
1500         
 8 1.25 ± 0.37 0.1274
Vehicle Control No Stressor 
 0         
 8 0.50 ± 0.33 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed