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Study Information
Study Attribute Value
CEBS Accession Number: 002-02231-0001-0000-1
Chemical Name: HC red 3
CASRN: 2871-01-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 828169_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 06/18/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1010 464 0.459 9.28 26.0 0.000
Test Chemical HC red 3 
50         
 16 325 270 0.831 16.88 26.0 80.836 
166.7       
 50 1040 1145 1.101 22.90 32.0 139.649 
500         
 25 525 931 1.773 37.24 32.0 286.006 
1700         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1043 673 0.645 13.46 26.0 40.454
Mitomycin-C 
 0.01      
 5 107 224 2.093 44.80 26.0 355.688
Trend: 24.720        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 07/08/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 25 523 196 0.375 7.84 25.5 0.000
Test Chemical HC red 3 
40         
 25 513 433 0.844 17.32 25.5 125.225 
133.3       
 25 513 479 0.934 19.16 25.5 149.152 
400         
 25 526 738 1.403 29.52 32.5 274.383 
1333         
 0 0 0 0.000 0.00 32.5 N/A
Positive Control Mitomycin-C 
 0.001     
 25 519 351 0.676 14.04 25.5 80.462
Mitomycin-C 
 0.01      
 5 106 177 1.670 35.40 25.5 345.567
Trend: 17.192        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/18/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1031 517 0.501 10.34 26.0 0.000
Test Chemical HC red 3 
500         
 50 1047 645 0.616 12.90 26.0 22.852 
1700         
 50 1044 824 0.789 16.48 26.0 57.396 
5000         
 50 1043 1182 1.133 23.64 26.0 125.996
Positive Control Cyclophosphamide 
 0.4       
 50 1025 600 0.585 12.00 26.0 16.734
Cyclophosphamide 
2         
 5 101 116 1.149 23.20 26.0 129.037
Trend: 17.020        
Probability: 0.000