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Study Information
Study Attribute Value
CEBS Accession Number: 002-02234-0001-0000-4
Chemical Name: Halothane
CASRN: 151-67-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 916871_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 01/20/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 512 0.489 10.24 26.0 0.000
Test Chemical Halothane 
160         
 50 1047 438 0.418 8.76 26.0 -14.371 
500         
 50 1048 473 0.451 9.46 26.0 -7.617 
1600         
 50 1048 470 0.448 9.40 26.0 -8.203
Positive Control Mitomycin-C 
 0.005     
 50 1050 846 0.806 16.92 26.0 64.920
Trend: -0.941        
Probability: 0.827        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/20/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 480 0.457 9.60 26.0 0.000
Test Chemical Halothane 
500         
 50 1047 395 0.377 7.90 26.0 -17.473 
1600         
 50 1046 408 0.390 8.16 26.0 -14.675 
5000         
 50 1050 449 0.428 8.98 28.0 -6.458
Positive Control Cyclophosphamide 
1         
 25 526 540 1.027 21.60 26.0 124.572
Trend: -0.859        
Probability: 0.805