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Study Information
Study Attribute Value
CEBS Accession Number: 002-02235-0001-0000-5
Chemical Name: Hamamelis water (witch hazel)
CASRN: 68916-39-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 187545_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 05/19/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1046 375 0.359 7.50 26.0 0.000
Test Chemical Hamamelis water (witch hazel) 
500         
 50 1051 411 0.391 8.22 26.0 9.079 
1600         
 50 1048 414 0.395 8.28 26.0 10.189 
5000         
 50 1049 419 0.399 8.38 26.0 11.414
Positive Control Mitomycin-C 
 0.005     
 25 525 713 1.358 28.52 26.0 278.818
Trend: 1.476        
Probability: 0.070        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/19/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 150 3131 1584 0.506 10.56 26.0 0.000
Test Chemical Hamamelis water (witch hazel) 
160         
 50 1044 610 0.584 12.20 26.0 15.493 
500         
 50 1050 585 0.557 11.70 26.0 10.127 
1600         
 50 1047 539 0.515 10.78 26.0 1.758 
5000         
 50 1045 572 0.547 11.44 26.0 8.195
Positive Control Cyclophosphamide 
1         
 50 1046 872 0.834 17.44 26.0 64.783
Trend: 1.296        
Probability: 0.098