Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02235-0001-0000-5 |
Chemical Name: | Hamamelis water (witch hazel) |
CASRN: | 68916-39-2 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 187545_SCE |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 | 50 | 1046 | 375 | 0.359 | 7.50 | 26.0 | 0.000 |
Test Chemical | Hamamelis water (witch hazel) | 500 | 50 | 1051 | 411 | 0.391 | 8.22 | 26.0 | 9.079 |
1600 | 50 | 1048 | 414 | 0.395 | 8.28 | 26.0 | 10.189 | ||
5000 | 50 | 1049 | 419 | 0.399 | 8.38 | 26.0 | 11.414 | ||
Positive Control | Mitomycin-C | 0.005 | 25 | 525 | 713 | 1.358 | 28.52 | 26.0 | 278.818 |
Trend: | 1.476 | ||||||||
Probability: | 0.070 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 | 150 | 3131 | 1584 | 0.506 | 10.56 | 26.0 | 0.000 |
Test Chemical | Hamamelis water (witch hazel) | 160 | 50 | 1044 | 610 | 0.584 | 12.20 | 26.0 | 15.493 |
500 | 50 | 1050 | 585 | 0.557 | 11.70 | 26.0 | 10.127 | ||
1600 | 50 | 1047 | 539 | 0.515 | 10.78 | 26.0 | 1.758 | ||
5000 | 50 | 1045 | 572 | 0.547 | 11.44 | 26.0 | 8.195 | ||
Positive Control | Cyclophosphamide | 1 | 50 | 1046 | 872 | 0.834 | 17.44 | 26.0 | 64.783 |
Trend: | 1.296 | ||||||||
Probability: | 0.098 |