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Study Information
Study Attribute Value
CEBS Accession Number: 002-02235-0002-0000-6
Chemical Name: Hamamelis water (witch hazel)
CASRN: 68916-39-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 187545_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 05/19/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 100 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0 0 0.000 0.0
Test Chemical: Hamamelis water (witch hazel) 
500         
 100 5 0.050 5.0 2 0.020 2.0 3 0.030 3.0 0 0.000 0.0 
1600         
 100 8 0.080 8.0 1 0.010 1.0 7 0.070 7.0 0 0.000 0.0 
5000         
 100 7 0.070 7.0 2 0.020 2.0 5 0.050 5.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 100 42 0.420 31.0 17 0.170 16.0 24 0.240 21.0 1 0.010 1.0
Trend: 1.133 1.004 0.740  
Probability: 0.129 0.158 0.230  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/19/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 100 8 0.080 6.0 2 0.020 2.0 6 0.060 4.0 0 0.000 0.0
Test Chemical: Hamamelis water (witch hazel) 
500         
 100 15 0.150 12.0 2 0.020 2.0 13 0.130 11.0 0 0.000 0.0 
1600         
 100 15 0.150 11.0 3 0.030 3.0 12 0.120 9.0 0 0.000 0.0 
5000         
 100 20 0.200 14.0 3 0.030 3.0 17 0.170 12.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 25 0.250 21.0 7 0.070 6.0 18 0.180 16.0 0 0.000 0.0
Trend: 1.659 0.574 1.717  
Probability: 0.049 0.283 0.043