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Study Information
Study Attribute Value
CEBS Accession Number: 002-02235-0009-0000-3
Chemical Name: Hamamelis water (witch hazel)
CASRN: 68916-39-2
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 042552_SCE
Study Result: Negative


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 05/05/87 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 4 3.62 ± 0.539
Test Chemical Hamamelis water (witch hazel) 
1250         
 4 4.61 ± 0.615
  
2500         
 4 5.84 ± 0.701
  
5000         
 4 4.97 ± 0.323
Positive Control Mitomycin-C 
 0.5       
 4 8.28 ± 1.426


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 01/03/90 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 4 3.37 ± 0.277
Test Chemical Hamamelis water (witch hazel) 
1250         
 4 4.65 ± 0.477
  
2500         
 4 2.98 ± 0.143
  
5000         
 4 5.04 ± 1.103
Positive Control Mitomycin-C 
 0.5       
 4 9.10 ± 1.013


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed