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Study Information
Study Attribute Value
CEBS Accession Number: 002-02235-0010-0000-5
Chemical Name: Hamamelis water (witch hazel)
CASRN: 68916-39-2
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 042552_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 05/04/87 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.9214
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 12.25 ± 3.41 0.0011
Test Chemical Hamamelis water (witch hazel) 
1250         
 8 1.75 ± 1.22 0.9991
  
2500         
 8 2.75 ± 1.00 0.9877
  
5000         
 8 3.25 ± 1.19 0.9680
Vehicle Control No Stressor 
 0         
 8 6.00 ± 1.31 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 07/28/88 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.2872
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 9.00 ± 1.89 0.0000
Test Chemical Hamamelis water (witch hazel) 
1250         
 8 4.25 ± 1.39 0.0047
  
2500         
 8 2.00 ± 0.76 0.2008
  
5000         
 8 2.75 ± 0.84 0.0649
Vehicle Control No Stressor 
 0         
 8 1.25 ± 0.75 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 09/23/92 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.6977
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 9.00 ± 2.51 0.0000
Test Chemical Hamamelis water (witch hazel) 
1250         
 8 1.50 ± 0.50 0.1573
  
2500         
 8 0.25 ± 0.25 0.8420
  
5000         
 8 0.75 ± 0.37 0.5000
Vehicle Control No Stressor 
 0         
 8 0.75 ± 0.37 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed