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Study Information
Study Attribute Value
CEBS Accession Number: 002-02240-0001-0000-1
Chemical Name: Hexabromobiphenyl
CASRN: 36355-01-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 327202_SCE
Study Result: Equivocal

Study Result: Equivocal
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Questionable 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 03/19/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1025 410 0.400 8.20 26.0 -25.989
Dimethyl Sulfoxide 
0         
 50 1038 561 0.540 11.22 26.0 0.000
Test Chemical Hexabromobiphenyl 
5         
 50 1034 472 0.456 9.44 26.0 -15.539 
16.67      
 50 1032 541 0.524 10.82 26.0 -3.004 
50         
 50 1013 450 0.444 9.00 26.0 -17.806 
167         
 0 0 0 0.000 0.00 30.0 N/A
Positive Control Triethylenemelamine 
15         
 50 1039 1946 1.873 38.92 26.0 246.547
Trend: -2.215        
Probability: 0.987        

Trial #: 2    Activation: No Activation    Date: 04/22/1981    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1043 495 0.475 9.90 26.0 -3.209
Dimethyl Sulfoxide 
0         
 50 1034 507 0.490 10.14 26.0 0.000
Test Chemical Hexabromobiphenyl 
60         
 50 1026 501 0.488 10.02 29.0 -0.413 
80         
 50 1031 581 0.564 11.62 34.3 14.929 
100         
 50 1037 590 0.569 11.80 34.3 16.034
Positive Control Triethylenemelamine 
15         
 50 1028 974 0.947 19.48 26.0 93.232
Trend: 3.123        
Probability: 0.001        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/25/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1029 460 0.447 9.20 26.0 0.000
Negative (Not Specified) 
0         
 50 1022 446 0.436 8.92 26.0 -2.379
Test Chemical Hexabromobiphenyl 
50         
 50 1023 447 0.437 8.94 26.0 -2.256 
166.7       
 50 1045 394 0.377 7.88 26.0 -15.659 
500         
 50 1030 405 0.393 8.10 26.0 -12.042
Positive Control Cyclophosphamide 
1.5       
 50 1046 1246 1.191 24.92 26.0 166.467
Trend: -2.500        
Probability: 0.994