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Study Information
Study Attribute Value
CEBS Accession Number: 002-02240-0002-0000-2
Chemical Name: Hexabromobiphenyl
CASRN: 36355-01-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 327202_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 03/24/1981    Harvest Time: 10.8 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 4 0.040 4.0 3 0.030 3.0 0 0.000 0.0 1 0.010 1.0
Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 3 0.030 3.0 0 0.000 0.0 1 0.010 1.0
Test Chemical: Hexabromobiphenyl 
50         
 100 9 0.090 4.0 1 0.010 1.0 7 0.070 2.0 1 0.010 1.0 
167         
 100 12 0.120 6.0 2 0.020 2.0 10 0.100 4.0 0 0.000 0.0 
500         
 75 7 0.093 4.0 2 0.027 3.0 5 0.067 3.0 0 0.000 0.0
Positive Control: Triethylenemelamine 
 0.25      
 100 18 0.180 17.0 10 0.100 10.0 8 0.080 7.0 0 0.000 0.0
Trend: 0.289 0.062 1.706  
Probability: 0.386 0.475 0.044  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/15/1981    Harvest Time: 10.8 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 5 0.050 5.0 5 0.050 5.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 4 0.040 3.0 3 0.030 2.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Hexabromobiphenyl 
300         
 100 6 0.060 6.0 5 0.050 5.0 1 0.010 1.0 0 0.000 0.0 
400         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
500         
 100 6 0.060 6.0 1 0.010 1.0 5 0.050 5.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
25         
 100 23 0.230 18.0 14 0.140 13.0 9 0.090 9.0 0 0.000 0.0
Trend: 0.365 -1.340 1.851  
Probability: 0.358 0.910 0.032