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Study Information
Study Attribute Value
CEBS Accession Number: 002-02242-0001-0000-3
Chemical Name: Hexachloro-1,3-butadiene
CASRN: 87-68-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 635625_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 07/21/1981    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 426 0.408 8.52 25.8 0.000
Test Chemical Hexachloro-1,3-butadiene 
1.4       
 50 1040 556 0.535 11.12 25.8 31.144 
4.21      
 50 1045 594 0.568 11.88 25.8 39.437 
14         
 50 1040 1000 0.962 20.00 34.3 135.870
Positive Control Triethylenemelamine 
 0.015     
 50 1039 2240 2.156 44.80 25.8 428.858
Trend: 15.669        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/21/1981    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1019 356 0.349 7.12 25.8 0.000
Test Chemical Hexachloro-1,3-butadiene 
1.4       
 50 1032 384 0.372 7.68 25.8 6.506 
4.21      
 50 1045 496 0.475 9.92 25.8 35.859 
14         
 25 507 372 0.734 14.88 25.8 110.019
Positive Control Cyclophosphamide 
1.5       
 50 1037 1153 1.112 23.06 25.8 218.255
Trend: 10.261        
Probability: 0.000