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Study Information
Study Attribute Value
CEBS Accession Number: 002-02242-0002-0000-4
Chemical Name: Hexachloro-1,3-butadiene
CASRN: 87-68-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 635625_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 08/31/1981    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 7 0.070 7.0 4 0.040 4.0 1 0.010 1.0 2 0.020 2.0
Test Chemical: Hexachloro-1,3-butadiene 
24.87      
 100 8 0.080 8.0 2 0.020 2.0 6 0.060 6.0 0 0.000 0.0 
29.93      
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 
34.98      
 100 8 0.080 3.0 2 0.020 2.0 6 0.060 2.0 0 0.000 0.0
Positive Control: Triethylenemelamine 
 0.75      
 100 29 0.290 23.0 15 0.150 14.0 14 0.140 10.0 0 0.000 0.0
Trend: -1.727 -0.864 -0.320  
Probability: 0.958 0.806 0.626  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/31/1981    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 5 0.050 2.0 0 0.000 0.0 5 0.050 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Hexachloro-1,3-butadiene 
15.17      
 100 5 0.050 4.0 0 0.000 0.0 2 0.020 1.0 3 0.030 3.0 
19.81      
 100 9 0.090 7.0 3 0.030 3.0 6 0.060 4.0 0 0.000 0.0 
24.87      
 100 3 0.030 3.0 1 0.010 1.0 1 0.010 1.0 1 0.010 1.0
Positive Control: Cyclophosphamide 
50         
 100 45 0.450 28.0 25 0.250 20.0 18 0.180 13.0 2 0.020 2.0
Trend: 0.733 0.044 1.167  
Probability: 0.232 0.483 0.122