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Study Information
Study Attribute Value
CEBS Accession Number: 002-02245-0001-0000-6
Chemical Name: Hexachlorocyclopentadiene
CASRN: 77-47-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 353427_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 11/08/1988    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1028 369 0.359 7.38 26.0 0.000
Test Chemical Hexachlorocyclopentadiene 
 0.016     
 50 1030 405 0.393 8.10 26.0 9.543 
 0.05      
 50 1037 413 0.398 8.26 26.0 10.953 
 0.16      
 50 1024 469 0.458 9.38 26.0 27.597 
 0.5       
 50 1025 432 0.421 8.64 26.0 17.416
Positive Control Mitomycin-C 
 0.0E-4    
 50 1022 519 0.508 10.38 26.0 41.476
Mitomycin-C 
 0.005     
 10 206 263 1.277 26.30 26.0 255.677
Trend: 3.023        
Probability: 0.001        

Trial #: 2    Activation: No Activation    Date: 12/13/1988    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 383 0.366 7.66 26.0 0.000
Test Chemical Hexachlorocyclopentadiene 
 0.05      
 50 1039 514 0.495 10.28 26.0 35.108 
 0.1       
 50 1041 468 0.450 9.36 26.0 22.780 
 0.16      
 50 1041 436 0.419 8.72 26.0 14.385 
 0.5       
 50 1046 538 0.514 10.76 26.0 40.470
Positive Control Mitomycin-C 
 0.0E-4    
 50 1047 501 0.479 10.02 26.0 30.684
Mitomycin-C 
 0.005     
 10 210 317 1.510 31.70 26.0 312.262
Trend: 3.745        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/08/1988    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1044 408 0.391 8.16 26.0 0.000
Test Chemical Hexachlorocyclopentadiene 
 0.16      
 50 1041 379 0.364 7.58 26.0 -6.840 
 0.5       
 50 1032 439 0.425 8.78 26.0 8.849 
1.6       
 50 1036 511 0.493 10.22 26.0 26.212 
5         
 50 1045 441 0.422 8.82 26.0 7.985
Positive Control Cyclophosphamide 
 0.15      
 50 1039 509 0.490 10.18 26.0 25.355
Cyclophosphamide 
 0.6       
 10 206 191 0.927 19.10 26.0 137.250
Trend: 3.019        
Probability: 0.001