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Study Information
Study Attribute Value
CEBS Accession Number: 002-02245-0002-0000-7
Chemical Name: Hexachlorocyclopentadiene
CASRN: 77-47-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 353427_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
Induced Rat Liver S9  1_S9  Weakly Positive* 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 12/15/1988    Harvest Time: 12 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Hexachlorocyclopentadiene 
 0.5       
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 
1         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
1.6       
 200 10 0.050 4.0 0 0.000 0.0 9 0.045 3.5 1 0.005 1.0 
3         
 19 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.125     
 200 48 0.240 21.5 16 0.080 7.5 32 0.160 15.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 16 0.320 28.0 7 0.140 10.0 9 0.180 18.0 0 0.000 0.0
Trend: 2.278 -0.500 2.264  
Probability: 0.011 0.692 0.012  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 12/15/1988    Harvest Time: 13 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Hexachlorocyclopentadiene 
1.6       
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0 
3         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
5         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
10         
 136 43 0.316 21.3 3 0.022 2.2 40 0.294 19.9 0 0.000 0.0
Positive Control: Cyclophosphamide 
5         
 200 29 0.145 14.0 9 0.045 4.5 20 0.100 10.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 18 0.360 32.0 3 0.060 6.0 14 0.280 28.0 1 0.020 1.0
Trend: 8.126 2.110 8.037  
Probability: 0.000 0.017 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 01/17/1989    Harvest Time: 13 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Hexachlorocyclopentadiene 
3         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0 
5         
 200 6 0.030 3.0 0 0.000 0.0 4 0.020 2.0 2 0.010 2.0 
7.5       
 200 28 0.140 9.5 1 0.005 0.5 25 0.125 8.0 2 0.010 2.0
Positive Control: Cyclophosphamide 
5         
 200 34 0.170 15.5 7 0.035 3.5 27 0.135 13.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 27 0.540 50.0 11 0.220 20.0 16 0.320 32.0 0 0.000 0.0
Trend: 4.906 1.301 4.352  
Probability: 0.000 0.097 0.000