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Study Information
Study Attribute Value
CEBS Accession Number: 002-02246-0001-0000-7
Chemical Name: Hexachloroethane
CASRN: 67-72-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 415312_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 05/10/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1044 432 0.414 8.64 25.7 0.000
Test Chemical Hexachloroethane 
10         
 50 1046 446 0.426 8.92 25.7 3.043 
33         
 50 1042 471 0.452 9.42 25.7 9.237 
100         
 50 1042 482 0.463 9.64 25.7 11.788 
330         
 0 0 0 0.000 0.00 33.0 N/A
Positive Control Mitomycin-C 
 0.005     
 25 520 675 1.298 27.00 25.7 213.702
Trend: 1.879        
Probability: 0.030        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/10/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1043 481 0.461 9.62 25.7 0.000
Test Chemical Hexachloroethane 
100         
 50 1043 471 0.452 9.42 25.7 -2.079 
330         
 50 1048 622 0.594 12.44 33.2 28.697 
1000         
 50 1042 682 0.655 13.64 33.2 41.924
Positive Control Cyclophosphamide 
1.5       
 25 522 801 1.534 32.04 25.7 232.737
Trend: 7.105        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 06/23/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1042 435 0.417 8.70 25.3 0.000
Test Chemical Hexachloroethane 
400         
 50 1032 585 0.567 11.70 35.8 35.786 
600         
 50 1044 627 0.601 12.54 35.8 43.862 
800         
 0 0 0 0.000 0.00 35.8 N/A 
1000         
 50 1048 638 0.609 12.76 35.8 45.827
Positive Control Cyclophosphamide 
1.5       
 25 520 889 1.710 35.56 25.3 309.522
Trend: 5.548        
Probability: 0.000