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Study Information
Study Attribute Value
CEBS Accession Number: 002-02246-0002-0000-8
Chemical Name: Hexachloroethane
CASRN: 67-72-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 415312_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Questionable 
Induced Rat Liver S9  2_S9  Negative 
No Activation  3  Negative 

Trial #:1   Activation: No Activation    Date: 11/10/1982    Harvest Time: 21.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0 2 0.020 2.0
Test Chemical: Hexachloroethane 
200         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
250         
 100 6 0.060 6.0 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 
300         
 100 3 0.030 3.0 0 0.000 0.0 2 0.020 2.0 1 0.010 1.0
Positive Control: Mitomycin-C 
 0.062     
 50 25 0.500 36.0 15 0.300 30.0 10 0.200 18.0 0 0.000 0.0
Trend: 1.116 0.534 1.808  
Probability: 0.132 0.297 0.035  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/11/1982    Harvest Time: 20 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 3 0.030 3.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Hexachloroethane 
800         
 100 9 0.090 5.0 7 0.070 4.0 2 0.020 2.0 0 0.000 0.0 
900         
 100 4 0.040 4.0 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 
1000         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
10         
 50 14 0.280 24.0 8 0.160 14.0 6 0.120 10.0 0 0.000 0.0
Trend: -0.477 -1.653 0.995  
Probability: 0.683 0.951 0.160  


Trial #:2   Activation: No Activation    Date: 08/11/1982    Harvest Time: 20 hour(s)   Trial Call: Questionable   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 6 0.060 5.0 2 0.020 2.0 4 0.040 3.0 0 0.000 0.0
Test Chemical: Hexachloroethane 
200         
 100 29 0.290 15.0 5 0.050 5.0 9 0.090 6.0 15 0.150 6.0 
300         
 50 3 0.060 6.0 1 0.020 2.0 2 0.040 4.0 0 0.000 0.0 
400         
 50 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.065     
 50 9 0.180 18.0 6 0.120 12.0 3 0.060 6.0 0 0.000 0.0
Trend: -1.188 -0.785 -0.790  
Probability: 0.883 0.784 0.785  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 05/28/1982    Harvest Time: 20.3 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0
Dimethyl Sulfoxide 
0         
 100 6 0.060 6.0 3 0.030 3.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: Hexachloroethane 
800         
 100 4 0.040 4.0 3 0.030 3.0 1 0.010 1.0 0 0.000 0.0 
900         
 100 10 0.100 7.0 6 0.060 3.0 1 0.010 1.0 3 0.030 3.0 
1000         
 100 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0
Positive Control: Cyclophosphamide 
15         
 50 52 1.040 44.0 33 0.660 36.0 9 0.180 14.0 10 0.200 1.0
Trend: -0.915 -0.846 -1.807  
Probability: 0.820 0.801 0.965  


Trial #:3   Activation: No Activation    Date: 05/28/1982    Harvest Time: 20 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 50 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Hexachloroethane 
150         
 50 1 0.020 2.0 0 0.000 0.0 0 0.000 0.0 1 0.020 2.0 
250         
 50 1 0.020 2.0 0 0.000 0.0 0 0.000 0.0 1 0.020 2.0 
500         
 25 1 0.040 4.0 0 0.000 0.0 1 0.040 4.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.065     
 25 9 0.360 28.0 3 0.120 12.0 6 0.240 20.0 0 0.000 0.0
Trend: 1.233 0.000 1.759  
Probability: 0.109 0.000 0.039