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Study Information
Study Attribute Value
CEBS Accession Number: 002-02250-0001-0000-2
Chemical Name: Hexamethyl-p-rosaniline chloride
CASRN: 548-62-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 126650_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 11/23/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1029 505 0.491 10.10 25.5 0.000
Test Chemical Hexamethyl-p-rosaniline chloride 
 0.075     
 50 1009 463 0.459 9.26 25.5 -6.500 
 0.1       
 50 1024 536 0.523 10.72 32.5 6.657 
 0.12      
 50 1026 552 0.538 11.04 32.5 9.627 
 0.2       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1035 715 0.691 14.30 25.5 40.763
Mitomycin-C 
 0.01      
 5 100 266 2.660 53.20 25.5 442.008
Trend: 1.972        
Probability: 0.024        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/02/1982    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1018 462 0.454 9.24 25.5 0.000
Test Chemical Hexamethyl-p-rosaniline chloride 
 0.1       
 50 1025 430 0.420 8.60 25.5 -7.562 
 0.333     
 17 350 212 0.606 12.47 32.7 33.467 
1         
 0 0 0 0.000 0.00 0.0 N/A
Trend: 2.545        
Probability: 0.005        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 11/23/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1020 413 0.405 8.26 25.5 0.000
Test Chemical Hexamethyl-p-rosaniline chloride 
 0.35      
 50 1028 434 0.422 8.68 25.5 4.267 
 0.4       
 50 1027 485 0.472 9.70 25.5 16.633 
 0.5       
 50 1013 453 0.447 9.06 32.5 10.443
Positive Control Cyclophosphamide 
 0.3       
 50 1029 508 0.494 10.16 25.5 21.927
Cyclophosphamide 
2         
 5 102 142 1.392 28.40 25.5 243.826
Trend: 1.758        
Probability: 0.039