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Study Information
Study Attribute Value
CEBS Accession Number: 002-02254-0007-0000-2
Chemical Name: Hexamethylphosphoramide
CASRN: 680-31-9
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: A48570_CA
Study Result: Positive (Nonstandard Protocol)

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 06/07/83 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0101
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Test Chemical Hexamethylphosphoramide 
500         
 4 5.75 ± 1.44 0.0058
  
1000         
 4 8.75 ± 1.75 0.0000
  
2000         
 4 6.25 ± 1.18 0.0025
Vehicle Control No Stressor 
 0         
 4 2.25 ± 0.95 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed